Dr. Alejandro Soto-Gutiérrez is an Assistant Professor in the Department of Pathology at the University of Pittsburgh. He is also a faculty member of the McGowan Institute, and the Thomas E. Starzl Transplantation Institute. Prior to this he was a Surgery Research Fellow with the Department of Surgery at Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children in Boston. Dr. Soto-Gutiérrez earned his medical degree at the University of Guadalajara, Mexico. He worked on his doctorate at the Department of Surgery of Okayama University Graduate School of Medicine and Dentistry, Japan, where he wrote his dissertation on liver tissue engineering. He is member of the National System of Investigators (SNI) Level 2 from the National Council of Science and Technology (CONACYT), Mexico. He won the 2008 Clinical Research Award for a Post-Graduate Fellow in Transplantation from the New England Organ Bank and the 2009 Thomas E. Starzl, MD Postdoctoral Research Award from the American Liver Foundation and the 2012 faculty development award from the American Society of Transplantation. He has been awarded a National Institutes of Health Pathway to Independence Award (K99/R00). He is author of more than seventhy peer-reviewed publications, eight book chapters and edited a book on methods in cell transplantation.Dr. Soto-Gutierrez's research is focused on the development of new technologies for organ replacement using regenerative medicine approaches (bioengineering, cell transplantation and organ engineering) to generating entire replacement organs, Dr. Soto-Gutierrez's laboratory use the structural connective tissue of discarded livers as a scaffold for growing new liver tissue for transplantation and primary liver isolated cells. His laboratory is actively working in liver cell differentiation and understanding hepatic maturation of ES or iPS cells using interactions with liver non-parenchymal liver cells, 3D liver matrix and different molecules. While portions of the studies are carried out in organ culture systems, several ongoing studies are performed in special animal models of liver regeneration to understand hepatic tissue assembling and regeneration using auxiliary partial orthotopic liver transplantation (APOLT). In addition, Dr. Soto-Gutierrez's laboratory is also interested in strategies for liver repopulation and the study and generation of liver regeneration in disease state models (e.g. acute or chronic liver failure and liver steatosis using metabolic engineering techniques). To this end, several lines of collaboration are open with different laboratories in the Department of Pathology and the STI. .